In India, Tuberculosis (TB) became a major public-health problem having the maximum number of incident and multidrug-resistant (MDR) TB cases. Chemotherapy of current tuberculosis (TB) is based on a combination of various drugs that were developed generally in the central decades of the previous century. Drug sensitive strains of Mycobacterium tuberculosis (M. TB) shows high cure rates, When the recommended compound and lengthy treatment protocols are adhered to. In this article the various TB tests are used to predict the severity of disease. This article highlights problems related to the optimized use of existing potent drugs, challenges related to the development of novel, potent and improved products, focusing on inherent in TB drug clinical development.
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